What triggers the release of aldosterone to increase blood pressure?

The release of aldosterone is primarily triggered by low blood pressure. When blood pressure drops, the kidneys sense this change and respond by activating the renin-angiotensin-aldosterone system (RAAS). Renin is released from the juxtaglomerular cells in the kidneys, leading to the conversion of angiotensinogen to angiotensin I, which is further converted to angiotensin II by angiotensin-converting enzyme (ACE) primarily in the lungs.

Angiotensin II has several important effects, one of which is to stimulate the adrenal cortex to release aldosterone. Aldosterone acts on the nephron in the kidneys to promote sodium reabsorption. As sodium is reabsorbed, water follows, resulting in an increase in blood volume and consequently, an increase in blood pressure. This mechanism is critical in the body’s ability to maintain blood pressure homeostasis, especially during states of low blood volume or pressure.

While factors such as high blood volume, high sodium levels, and increased heart rate can influence blood pressure regulation, they do not directly initiate the release of aldosterone in the way that low blood pressure does. High blood volume would typically inhibit renin release and thus lower aldosterone levels, whereas high sodium levels